Periodic Fever/Autoinflammatory Disorders NGS Panel

  • Panel Description
  • Test Description
  • CPT Codes

Panel Description

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Test Description

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  • Sequencing
  • Del/Dup
  • Rush /STAT
  • MCC
3 - 5 weeks
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AP1S3, CARD14, CECR1, ELANE, HAX1, IL10, IL10RA, IL10RB, IL1RN, IL36RN, LPIN2, MEFV, MVK, NLRC4, NLRP12, NLRP3, NLRP7, NOD2, PLCG2, PSMB8, PSTPIP1, RBCK1, SH3BP2, SLC29A3, TMEM173, TNFRSF11A, TNFRSF1A, NLRP1 ( 28 genes )
96% at 20x
Blood (two 4ml EDTA tubes, lavender top) or Extracted DNA (3ug in TE buffer) or Buccal Swab or Saliva (kits available upon request)
All sequencing technologies have limitations. This analysis is performed by Next Generation Sequencing (NGS) and is designed to examine coding regions and splicing junctions. Although next generation sequencing technologies and our bioinformatics analysis significantly reduce the contribution of pseudogene sequences or other highly-homologous sequences, these may still occasionally interfere with the technical ability of the assay to identify pathogenic variant alleles in both sequencing and deletion/duplication analyses. Sanger sequencing is used to confirm variants with low quality scores and to meet coverage standards. If ordered, Del/Dup analysis is designed to identify deletions or duplications which are two or more contiguous exons in size. Identified putative deletions or duplications are confirmed by an orthogonal method (qPCR or MLPA). This assay will not detect certain types of genomic alterations which may cause disease such as, but not limited to, translocations or inversions, repeat expansions (eg. trinucleotides or hexanucleotides), alternations in most regulatory regions (promoter regions) or deep intronic regions (greater than 20bp from an exon). This assay is not designed or validated for the detection of somatic mosaicism or somatic mutations.

[[GENE_LIMITATIONS]]
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CPT Code 81401, 81402, 81404, 81479x2

DISCLAIMER:  CPT codes used to file medical claims to insurance companies are payer contract dependent. Please consult with your specific insurance company to determine the CPT codes to use for this panel. The CPT codes listed for the panel are the AMA codes for the genes in the panel only, they do not necessarily represent the codes which should be used to file with specific payer contracts for your organization. Different payers have slightly different CPT codes arrangements for each billable panel.

NOTE:  The CPT codes list on the website for our panels is just a list of CPT codes for the genes contained within. They are NOT the CPT codes we use to bill insurance companies. These are provided so customers can decide what to use when they bill their insurance company. If Fulgent is billing insurance directly, our policy for All-in-one and Whole-in-one is to bill the panel code(s) only.

Resources

Gene Descriptions

GeneReasonReference

Appendix